Uncharacterized DUF1574 leptospira proteins are SGNH hydrolases
نویسندگان
چکیده
منابع مشابه
A functional proteomic strategy to discover inhibitors for uncharacterized hydrolases.
Hydrolytic enzymes constitute one of the largest and most diverse protein classes in Nature. Of the four major classes of hydrolytic enzymes (aspartyl, cysteine, metallo, serine), serine hydrolases (SHs) are a particularly expansive family in mammals, representing ∼1% of the predicted protein products of the human genome.1 SHs play key roles in nearly all physiological and pathological processe...
متن کاملFunction Prediction of uncharacterized proteins
Function prediction of uncharacterized protein sequences generated by genome projects has emerged as an important focus for computational biology. We have categorized several approaches beyond traditional sequence similarity that utilize the overwhelmingly large amounts of available data for computational function prediction, including structure-, association (genomic context)-, interaction (ce...
متن کاملSafe Functional Inference for Uncharacterized Viral Proteins
blue represent proteins in homologous families A and B, while green and black denote other families C and D. Reported BLAST similarities are depicted by curved edges (bottom). A and C coincide on a multi-domain protein (pink and green protein) which may induce false-transitivity – falsely clustering A with nonhomologous C due to local BLAST similarities of multi-domain protein (red edges). Corr...
متن کاملAnnotation and curation of uncharacterized proteins- challenges
Hypothetical proteins (HPs) are the proteins predicted to be expressed from an open reading frame, making a substantial fraction of proteomes in both prokaryotes and eukaryotes. Genome projects have led to the identification of many therapeutic targets, the putative function of the protein, and their interactions. In this review we enlist various methods linking annotation to structural and fun...
متن کاملA Synthetic Lattice for Structure Determination of Uncharacterized Proteins
Proteins are constructed from amino acid chains which are folded into complex three-dimensional structures. Structural knowledge provides a molecular snapshot of the protein. Molecular pictures can assist scientists who wish to understand proteins, engineers who wish to modify either the proteins’ structures or functions, and drug designers who wish to cause large effects within an organism due...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cell Cycle
سال: 2008
ISSN: 1538-4101,1551-4005
DOI: 10.4161/cc.7.4.5386